In the first game of the season, a Monday Night Football match against the Houston Texans, Brees threw for 370 yards, two touchdowns, and one interception as the Saints overcame a slow start to win 30–28. In the Saints' Week 2 game against the Los Angeles Rams, Brees completed 3 of 5 passes for 38 yards and an interception before an injury to his right hand forced him out of the game. The next day, an MRI revealed that Brees had suffered a torn ligament in the thumb of his right hand, which would require surgery and reportedly cause him to miss six to eight weeks. Brees returned in Week 8 against the Arizona Cardinals, finishing with 373 passing yards, three touchdowns, and an interception as the Saints won 31–9. In Week 11 against the Tampa Bay Buccaneers, Brees threw for 228 yards and three touchdowns in the 34–17 win. In Week 12, against the Carolina Panthers, he passed for 311 yards, three touchdowns, and one interception in the 34–31 win. In Week 14 against the San Francisco 49ers, Brees completed 29 of 40 passes for 349 yards, five touchdowns and no interceptions and scored a one-yard rushing touchdown, but his efforts were in vain as the Saints narrowly lost 48–46. During Week 15 against the Indianapolis Colts on Monday Night Football, Brees broke former Colts quarterback Peyton Manning's record for most career touchdowns, throwing his 540th to tight end Josh Hill on his career-best 20th straight completion in the third quarter. Brees's record-breaking touchdown pass was his third touchdown pass on the night. He finished the game with four touchdowns and 304 yards as the Saints defeated the Colts by a 34–7 score. In addition, Brees completed 29 of his 30 pass attempts for a career high and NFL single game record 96.7% completion percentage rate, surpassing the previous record (28 out of 29 passes for a 96.6% completion percentage rate) which had been set the previous year by his former Chargers teammate Philip Rivers. In the following week's game against the Tennessee Titans, Brees threw for 279 yards and three touchdowns during the 38–28 win. During the game, Brees helped wide receiver Michael Thomas break the single season receptions record formerly held by Marvin Harrison with his 144th catch of the season. In Week 17 against the Carolina Panthers, Brees threw for 253 yards and three touchdowns during the 42–10 win. In the 2019 season, Brees appeared in 11 games and finished with 2,979 passing yards, 27 touchdowns, and four interceptions. He finished with a completion percentage of 74.34%, which finished second in NFL history to his record from the previous season.
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